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| c. 1500 |
| | Faenza becomes the main centre for the production of the Italian tin-glazed earthenware known as majolica | |
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| c. 1500 |
| | Leonardo argues that fossils in rocks far above the sea imply not the effects of the Flood but a change in the level of an ancient sea bed | |
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| c. 1500 |
| | The female mamakuna and the male yanakuna are selected in childhood to serve the Inca state | |
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| 1500 |
| | Portuguese explorer Pedro Cabral, with a fleet of thirteen ships, makes landfall in Brazil | |
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| c. 1500 |
| | The Inca empire has about 25,000 miles of well-serviced roads, designed for caravans of llamas | |
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| c. 1500 |
| | The manor of East Sheen and West Hall is carved out of the manor of Mortlake, including all that part of Kew that now lies between the river, the A316 and the District railway | |
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| c. 1500 |
| | The Portuguese establish trading posts in east Africa, on the coast of Mozambique | |
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| c. 1500 |
| | European diseases bring death on a massive scale to an American population that has no immunity | |
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| c. 1500 |
| | The Salic law, preventing inheritance of the throne by or through a woman, is by now accepted as a fundamental law of France | |
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| c. 1500 |
| | In Cuzco's great temple, the sacrifices are usually of llamas, occasionally of humans | |
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