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| 1576 |
| | | The Pacification of Ghent unites all the provinces of the Netherlands in opposition to Spain | |
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| 1576 |
| | | James Burbage builds London's first theatre and calls it the Theatre | |
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| c. 1576 |
| | | Danish astronomer Tycho Brahe builds Uraniborg, on the island of Hven, and makes it the world's leading observatory | |
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| 1577 |
| | | Francis Drake sails from Plymouth, heading west for the Pacific and the East Indies | |
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| 1577 |
| | | Domenikos Theotokopoulos moves to Spain, where he becomes known as El Greco | |
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| 1579 |
| | | Francis Drake seizes a Spanish vessel laden with gold and silver in the Pacific, formerly a safe area for Spain | |
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| 1579 |
| | | The Union of Arras and the Union of Utrecht split the Netherlands into Catholic and Protestant camps | |
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| 1579 |
| | | Queen Elizabeth buys the lease of Barn Elms for her spymaster, Sir Francis Walsingham | |
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| c. 1580 |
| | | Five tribal troups form a League of Five Nations, commonly known as the Iroquois League or Confederacy, against their common enemy the Huron | |
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| 1580 |
| | | A Spanish army marches into Portugal to claim the crown for the king of Spain, Philip II | |
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