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| c. 1180 |
| | | In Cairo the Jewish philosoper Moses Maimonides writes, in Arabic, a much translated text with the endearing title Guide to the Perplexed | |
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| c. 1200 |
| | | The new Christian doctrine of Transubstantiation prompts rumours that the Jews desecrate the consecrated Host | |
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| c. 1290 |
| | | The classical work of the Kabbalah, the Zohar, is almost certainly the work of the Spanish Kabbalist Moses de Leon | |
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| 1290 |
| | | The Jews in England are driven out of the country, soon to be followed by those in France | |
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| 1348 |
| | | Massacres of Jews, rumoured to have caused the Black Death by poisoning wells, begin in southern France and spread through much of Europe | |
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| 1480 |
| | | Tomas de Torquemada, from a family of converted Jews, is appointed Spain's first Grand Inquisitor | |
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| 1492 |
| | | Torquemada persuades Ferdinand and Isabella to expel from Spain all Jews (about 160,000) who will not convert to Christianity | |
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| 1492 |
| | | Bayazid II, the Turkish sultan, makes a special point of welcoming in Istanbul the Jews expelled from Spain | |
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| 1516 |
| | | The original ghetto is established as a district to which the Jews of Venice are confined | |
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| 1528 |
| | | Discussion of Henry VIII's proposed divorce hinges on rival verses from the Old Testament, in Deuteronomy and Leviticus | |
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