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| 1506 |
| | | Julius II, together with the architect Bramante, lays the foundation stone for the new St Peter's | |
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| 1508 |
| | | Michelangelo begins work in Rome on the ceiling of the Sistine chapel | |
|  | Study for The Creation of Adam Michelangelo, c.1508
British Museum
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| 1508 |
| | | Raphael is summoned to Rome by Julius II and is given a major commission for frescoes | |
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| 1509 |
| | | Raphael begins work on the frescoes in the pope's apartment in the Vatican, known as the Stanze ('Rooms') | |
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| 1510 |
| | | Giorgione and Titian introduce the richness of colour which characterizes the high Renaissance style in Venice | |
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| c. 1510 |
| | | The startling colour contrasts in Michelangelo's Sistine ceiling anticipate one of the main characteristics of Italian mannerism | |
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| 1510 |
| | | The painter Giorgione dies after a short but extremely influential life in Venice | |
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| 1515 |
| | | The king of France, Francis I, wins a dramatic victory at Marignano and captures Milan | |
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| 1516 |
| | | The original ghetto is established as a district to which the Jews of Venice are confined | |
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| 1516 |
| | | Ariosto, in Orlando Furioso, tells of Roland's madness when he is abandoned by the pagan princess Angelica | |
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