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| 1497 |
| | | Savonarola, in the carnival before Lent, urges the people of Florence to throw playing cards and lewd images on a great bonfire of vanities | |
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| 1498 |
| | | The Florentine mob, weary of puritanism, attacks the convent of San Marco and drags Savonarola away to be hanged and burnt | |
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| 1499 |
| | | 24-year-old Michelangelo provides for St Peter's in Rome an exquisite Pietà – the Virgin holding on her lap the dead Christ | |
|  | Pietà Michelangelo
Fotofile CG
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| c. 1500 |
| | | The first modern lock gates are installed on a canal in Milan, probably designed by Leonardo da Vinci | |
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| c. 1500 |
| | | Faenza becomes the main centre for the production of the Italian tin-glazed earthenware known as majolica | |
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| c. 1500 |
| | | Leonardo argues that fossils in rocks far above the sea imply not the effects of the Flood but a change in the level of an ancient sea bed | |
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| c. 1500 |
| | | Ceramic artists in Italy decorate large majolica dishes with scenes of narrative history, giving this style the name istoriato | |
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| 1501 |
| | | Michelangelo begins work in Florence on a tall thin slab of marble, which he transforms into David | |
|  | David Michelangelo
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| c. 1505 |
| | | Leonardo captures the enigmatic smile of Lisa Gherardini, known now as the Mona Lisa | |
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| 1505 |
| | | Pope Julius II summons Michelangelo to Rome to create the pope's own elaborately sculpted tomb | |
|  | One of the 'slaves' for the tomb of Julius II
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