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| c. 1350 |
| | | Armies of mercenaries, led by condottieri, conduct Italian warfare at an often extortionate rate | |
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| c. 1350 |
| | | Humanism, or the study of classical literature as a living tradition, develops into one of the main strands of the Renaissance | |
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| 1350 |
| | | Boccaccio, visiting Petrarch in Florence, is inspired to devote himself to the pursuit of classical studies | |
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| 1364 |
| | | A great clock is completed in Padua, regulated mechanically by foliot and escapement | |
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| 1377 |
| | | The papal curia returns to Rome in what would seem a conclusive move if there were not, two years later, two popes - one of them elected back in Avignon | |
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| 1378 |
| | | John Hawkwood, a condottiere in command of the White Company, is appointed captain general of Florence | |
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| 1379 |
| | | The French cardinals, objecting to the new Italian pope, elect their own man as Clement VII - and thus inaugurate the Great Schism of the papacy | |
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| 1380 |
| | | The Venetian blockade of Chioggia costs Genoa her fleet and ends Genoese rivalry with Venice in the eastern Mediterranean | |
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| 1384 |
| | | Gian Galeazzo Visconti, the signore of Milan, sets about enlarging his territory - seizing Vicenza, Verona and Padua between 1384 and 1388 | |
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| 1395 |
| | | Philip II of Burgundy commissions from Netherlands sculptor Claus Sluter a work, the Well of Moses, which launches the northern Renaissance | |
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