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| c. 100 BC |
| | The practice of acupuncture is described in Nei Qing, a Chinese medical text | |
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| -82 BC |
| | To escape from Italy Caesar joins the army, and serves in Asia with distinction (winning the Civic Crown for courage in action) | |
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| 64 BC |
| | Pompey takes Antioch and brings Syria under control as a Roman province | |
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| 64 BC |
| | The Roman annexation of Syria brings the Silk Road all the way to the Mediterranean | |
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| 63 BC |
| | Pompey captures Jerusalem, bringing Judaea under Roman control | |
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| 57 BC |
| | Silla becomes the first of the three kingdoms of Korea, followed by Koguryo in 37 BC and Paekche in 18 BC | |
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| 53 BC |
| | Crasssus is killed at Carrhae, in Turkey, when the Parthians defeat his army, largely thanks to their brilliance as mounted archers | |
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| 53 BC |
| | The death of Crassus at Carrhae brings to an end the first triumvirate | |
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| 51 BC |
| | The Xiongnu split into two hordes, one of them submitting to China and the other moving west | |
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| c. 50 BC |
| | The Phoenicians discover that a blob of molten glass can be puffed out to form a hollow vessel | |
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