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| 1921 |
| | | Agnes Macphail becomes the first woman to sit in Canada's parliament | |
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| 1922 |
| | | Canadian physiologists Frederick Banting and Charles Best isolate insulin from the pancreas for the treatment of diabetes | |
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| 1930 |
| | | In The Fur Trade in Canada Harold Innis traces the economic development linking the trade and the nation | |
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| 1930 |
| | | Conservative leader R.B. Bennett defeats the Liberals and becomes prime minister of Canada | |
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| 1931 |
| | | The Statute of Westminster defines and formalizes the concept of the British Commonwealth | |
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| 1933 |
| | | 25% of workers in Canada are unemployed as the Depression continues to deepen | |
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| 1934 |
| | | Five girls are born as quintuplets in the Dionne family of French Catholic farmers in Corbeil, Ontario | |
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| 1935 |
| | | Strikers in Vancouver begin the On-to-Ottawa Trek, to take their grievances to government | |
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| 1935 |
| | | W.L. Mackenzie King starts another long spell, of thirteen years, as Canadian prime minister | |
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| 1936 |
| | | The Canadian Broadcasting Corporation is founded as a public service in competition with private radio stations | |
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