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| 1853 |
| | | Just six weeks after the success of Il Trovatore, Giuseppe Verdi's opera La Traviata is a disaster at its premiere in Venice | |
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| 1853 |
| | | In a worsening diplomatic crisis, Russia puts her Black Sea fleet in a state of alert at Sebastopol | |
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| 1853 |
| | | Russia occupies two Ottoman principalities, Moldavia and Wallachia, on the west coast of the Black Sea | |
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| 1853 |
| | | In the expectation of British and French support, the Ottoman sultan declares war on Russia - launching the Crimean War | |
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| 1853 |
| | | The hypodermic syringe with a plunger is simultaneously developed in France and in Scotland | |
|  | Alexander Wood's hypodermic syringe
Wellcome Library, London
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| 1854 |
| | | English physician John Snow proves that cholera is spread by infected water (from a pump in London's Broad Street) | |
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| 1854 |
| | | Britain and France enter the war between Turkey and Russia, on the Turkish side | |
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| 1854 |
| | | A London editor decides to send a reporter, William Howard Russell ('Russell of The Times'), to the Crimean front | |
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| 1854 |
| | | British and French troops land at Sebastopol, to besiege the port, and win a limited victory over the Russians at the river Alma | |
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| 1854 |
| | | Florence Nightingale, responding to reports of horrors in the Crimea, sets sail with a party of twenty-eight nurses | |
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