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| 1735 |
| | | John Peter Zenger, editor of the Weekly Journal, is acquitted of libelling the governor of New York on the grounds that what he published was true | |
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| 1740 |
| | | Venezuela, Colombia and Ecuador become the Spanish viceroyalty of New Granada, with Bogota as the capital | |
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| 1741 |
| | | The American Magazine and the General Magazine both begin a short-lived existence | |
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| 1741 |
| | | American revivalism is inflamed by Jonathan Edwards' vivid sermon Sinners in the Hands of an Angry God | |
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| 1743 |
| | | Benjamin Franklin drafts in Philadelphia the founding document for the American Philosophical Society | |
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| 1744 |
| | | Franklin publishes his design for an improved stove in Account of the New Invented Pennsylvania Fire Place | |
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| 1745 |
| | | New England militiamen achieve an unexpected success in capturing the fortress of Louisbourg from the French | |
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| 1746 |
| | | An earthquake destroys much of Lima, and an ensuing tidal wave engulfs its port at Callao | |
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| 1749 |
| | | A French official travels down the Ohio valley, placing markers to claim it for France | |
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| 1752 |
| | | The French seize or evict every English-speaking trader in the region of the upper Ohio | |
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