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| 1525 |
| | Conrad Grebel baptises an adult, causing outrage in Protestant Zurich | |
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| 1531 |
| | Zwingli is killed at Kappel in a battle between Protestant and Catholic cantons | |
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| 1541 |
| | Protestant reformer John Calvin settles in Geneva and submits the city to a strict Christian rule | |
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| 1596 |
| | Swiss botanist Gaspard Bauhin begins work classifying 6000 plants on a new binomial system of nomenclature | |
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| 1603 |
| | Geneva wins independence from the duchy of Savoy, in the treaty of St Julien, after repelling a midnight assault on the city | |
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| 1647 |
| | The Swiss cantons agree on joint action to defend their external borders, in the pact known as the Defensionale of Wyl | |
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| 1836 |
| | Louis Agassiz builds a hut on the Aar glacier in Switzerland and succeeds in recording gradual movement of the ice | |
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| 1840 |
| | Swiss scientist Louis Agassiz argues, in his Study on Glaciers, that much of Europe was recently in the grip of an ice age | |
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| 1843 |
| | Swiss naturalist Louis Agassiz completes his pioneering Poissons Fossiles ('Fossil Fish'), classifying more than 1500 categories | |
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| 1862 |
| | Swiss humanitarian Henri Dunant publishes A Memory of Solferino, proposing an international agency to cope with the battlefield casualties he has witnessed | |
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