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c. 1460

Oil paints, long familiar in the Netherlands, begin to be adopted in Italy in place of tempera

1463

The assembly brought together in Bruges in 1463 is later seen as the first full gathering of the Netherlands States-General

c. 1468

Jerome van Aken works almost exclusively in his native s' Hertogenbosch, from which he derives the name Hieronymus Bosch

Bosch Christ Mocked (detail) c.1500
National Gallery, London

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c. 1475

Tommaso Portinari, the Medici agent in Bruges, commissions an altarpiece from Hugo van der Goes for his family church in Florence

1503

Hieronymus Bosch paints the most detailed of his exotically surreal canvases, The Garden of Earthly Delights

1510

Erasmus and Thomas More take the northern Renaissance in the direction of Christian humanism

1516

Erasmus publishes an influential edition of the New Testament in its original Greek

1536

William Tyndale is captured in Antwerp, condemned as a heretic and strangled at the stake

1543

Flemish anatomist Andreas Vesalius publishes a seven-volume work which for the first time lays bare human anatomy

c. 1565

Pieter Brueghel the Elder depicts biblical events taking place among the peasants of the Netherlands countryside

Pieter Brueghel the Elder Adoration of the Kings (detail) 1564
National Gallery, London

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