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| | | | Literature |
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| c. 400 BC |
| | | Daodejing ('The Way and the Power') is the book of Daoism | |
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| 399 BC |
| | | Socrates, convicted in Athens of impiety, is sentenced to death and drinks the hemlock | |
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| 387 BC |
| | | Plato establishes a school in Akademeia, a suburb of Athens | |
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| c. 380 BC |
| | | Central to Plato's philosophy is the theory that there are higher Forms of reality, of which our senses perceive only a transient shadow | |
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| 367 BC |
| | | Aristotle, at the age of seventeen, comes to Athens to join Plato's academy | |
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| c. 350 BC |
| | | The Mahabharata, India's great national epic, begins to take shape | |
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| c. 343 BC |
| | | Homer's Iliad becomes a profound source of inspiration to Alexander, who will keep scrolls of the text in his tent during his conquests | |
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| c. 330 BC |
| | | Aristotle tackles wide-ranging subjects on a systematic basis, leaving to his successors an encyclopedia of contemporary thought | |
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| c. 300 BC |
| | | The Indian epic of romance and adventure, the Ramayana, is probably the work of a single author at about this time | |
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| c. 280 BC |
| | | The Jews of Alexandria commission the Greek translation of the Old Testament which becomes known as the Septuagint | |
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