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| 1846 July22 |
| | | The first train on the new London and South Western Railway line from Nine Elms passes through Barnes on its way to a rapturous arrival in Richmond, with a brass band and church bells ringing | |
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| 1846 |
| | | Brigham Young leads the migration of Mormons west up the Missouri from Illinois | |
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| 1846 |
| | | Mendelssohn's oratorio Elijah has its premiere in England, in the city of Birmingham | |
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| 1846 |
| | | After marrying secretly, the English poets Robert Browning and Elizabeth Barrett go abroad to live in Florence | |
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| 1846 |
| | | The US Congress establishes the Smithsonian Institution with a bequest to the nation by Englishman James Smithson | |
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| 1846 |
| | | A dentist in Boston, William Morton, uses ether as an anaesthetic while surgeon John Collins Warren removes a tumour in a patient's neck | |
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| 1846 |
| | | Landlords in Scotland begin to clear crofters from Highland estates so as to provide pasture for sheep | |
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| 1846 |
| | | Members of the Donner Party, on the trail to California, survive by eating human flesh when trapped by snow in the mountains of the Sierra Nevada | |
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| 1846/7 |
| | | William Chillingworth, who bought Radnor House in 1842, substantially remodels it in the fashionable Italianate style. | |
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| 1846 |
| | | The three Brontë sisters jointly publish a volume of their poems and sell just two copies | |
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