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| 1846 |
| | | British prime minister Robert Peel carries a bill to repeal the Corn Laws, splitting his own party in the process | |
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| 1846 |
| | | Francis Parkman travels west into dangerous territory in Wyoming, an adventure he later describes in The Oregon Trail | |
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| c. 1846 |
| | | The Irish, fleeing from the potato famine at home, become the main group of immigrants to the USA | |
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| 1846 |
| | | The minority of Conservatives supporting Peel become a separate faction, henceforth known as the Peelites | |
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| 1846 |
| | | Edward Lear publishes his Book of Nonsense, consisting of limericks illustrated with his own cartoons | |
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| 1846 |
| | | The Oregon Treaty establishes the border between Canada and the USA along the 49th parallel to the Pacific | |
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| 1846 |
| | | Mary Anne Evans' translation from the German of David Friedrich Strauss's controversial Life of Jesus is published anonymously | |
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| 1846 |
| | | President Polk sends a US army into Texas, provoking the Mexican-American War | |
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| 1846 |
| | | Pugin completes his most spectacularly decorated church, that of St Giles in Cheadle, Staffordshire | |
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| 1846 |
| | | With his Conservative party split, Peel's government falls and Lord John Russell becomes British prime minister at the head of a Whig administration | |
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