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| 1621 |
| | | The Dutch West India Company is chartered to trade and found colonies anywhere along the entire American coast | |
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| 1621 |
| | | John Donne, England's leading Metaphysical poet, becomes dean of St Paul's | |
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| 1622 |
| | | A sudden attack by Powhatan Indians, led by their chieftain Opechancanough against the English colony at Jamestown, results in the death of more than 300 settlers | |
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| 1622 |
| | | Bernini's youthful Pluto and Proserpina, suggesting soft flesh in cold marble, introduces the lively tradition of baroque sculpture | |
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| 1622 |
| | | The Flemish painter Anthony van Dyck begins a five-year stay, and a successful career as a portrait painter, in Genoa | |
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| 1623 |
| | | Tne English settlers in Virginia arrange a peace conference with the Powhatan Indians, using it as an opportunity to murder the Powhatan delegates | |
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| 1623 |
| | | John Heminge and Henry Condell publish thirty-six Shakespeare plays in the First Folio | |
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| 1623 |
| | | Diego Velazquez becomes court painter to the king of Spain - a post which he will hold for the remaining thirty-seven years of his life | |
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| 1624 |
| | | The Japanese are forbidden to leave their country, or foreigners to enter, at the start of more than two centuries of almost total isolation | |
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| 1624 |
| | | Nicolas Poussin arrives in Rome, where he develops the tradition of French classicism | |
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