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| 1560 |
| | Tobacco is grown in Europe's physic gardens for its medicinal qualities | |
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| 1560 |
| | A year after Mary has become queen of France, her husband Francis II dies | |
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| 1561 |
| | Mary Queen of Scots returns from France to Edinburgh, and to an inevitable clash with John Knox | |
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| 1563 |
| | Philip II begins construction of the palace and monastery known as the Escorial | |
| | Escorial, near Madrid Fotofile CG
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| 1563 |
| | The Northern Seven Years' War breaks out between Denmark and Sweden | |
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| c. 1564 |
| | The bishop of Transylvania, Ferenc Dávid, preaches that only God the Father is divine, launching the Unitarian faith | |
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| 1564 |
| | Marlowe and Shakespeare are born in the same year, with Marlowe the older by two months | |
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| 1564 |
| | Gabriele Fallopia invents the condom | |
| | Swiss peasant family with 15 children
Wellcome Library, London
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| c. 1565 |
| | Pieter Brueghel the Elder depicts biblical events taking place among the peasants of the Netherlands countryside | |
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| 1565 |
| | Mary Queen of Scots marries her Catholic cousin, Henry Darnley | |
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