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| c. 1500 |
| | | Ceramic artists in Italy decorate large majolica dishes with scenes of narrative history, giving this style the name istoriato | |
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| 15001650 |
| | | A number of noblemen and wealthy merchants build their villas around Kew Green, including Robert Dudley Earl of Leicester, closely associated with Queen Elizabeth I. The only villa to survive from this period is the present Kew Palace built in the Dutch style
for Samuel Fortrey. | |
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| 1501 |
| | | The 14-year-old Ismail I is enthroned as shah of a new Persian dynasty, the Safavids | |
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| 1501 |
| | | Michelangelo begins work in Florence on a tall thin slab of marble, which he transforms into David | |
|  | David Michelangelo
Fotofile CG
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| 1501 |
| | | Italian navigator Amerigo Vespucci sets sail from Lisbon to explore to the south of the New World | |
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| 1501 |
| | | The rebuilding of Henry VII's palace is largely completed, after an impressively short time | |
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| 1502 |
| | | Vasco da Gama wins a trading treaty for Portuguese merchants after bombarding the Indian port of Calicut into submission | |
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| 1503 |
| | | The marriage of James IV, king of Scotland, to Margaret Tudor, daughter of Henry VII, leads a century later to the Union of the Crowns | |
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| 1503 |
| | | Hieronymus Bosch paints the most detailed of his exotically surreal canvases, The Garden of Earthly Delights | |
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| 1503 |
| | | The Portuguese set up a trading post on the east African island of Zanzibar | |
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