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| 1521 |
| | | Pope Leo X excommunicates Martin Luther after he has refused to recant | |
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| 1521 |
| | | Portuguese explorer Ferdinand Magellan crosses the Pacific in ninety-nine days and reaches Guam | |
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| 1521 |
| | | Luther travels to the German city of Worms to present his case to an imperial diet | |
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| 1521 |
| | | Ferdinand Magellan is killed in the Philippines, in a skirmish with natives | |
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| 1521 |
| | | Luther bears witness to a Protestant conscience, stating at Worms: 'Here I stand, I can not do otherwise.' | |
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| 1521 |
| | | The Turkish sultan, Suleiman I, marches into the kingdom of Hungary and captures Belgrade | |
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| 1521 |
| | | After a little more than a year Cortes recaptures Tenochtitlan and finally establishes Spanish control over Mexico | |
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| 1521 |
| | | Ignatius of Loyola, recovering from a wound received as a soldier at Pamplona, is inspired by reading the lives of the saints | |
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| 1522 |
| | | Outlawed by the Edict of Worms, Luther lives secretly in the Wartburg as Junker Georg | |
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| 1522 |
| | | Huldreich Zwingli eats sausage in Lent in Zurich, launching the Swiss Reformation | |
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