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| 1520 |
| | | The German painter Hans Holbein the Younger establishes his own studio in Basel | |
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| c. 1520 |
| | | Europe's new printing presses make possible the first pamphlet war, spreading instant arguments for and against the Reformation | |
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| 1520 |
| | | Luther's writings are burnt in Rome by order of the pope | |
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| 1520 |
| | | Cortes loses control of Tenochtitlan and has to escape in haste with his men during 'the Sorrowful Night' | |
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| 1520 |
| | | The English and French kings, Henry VIII and Francis I, feast and parley on the Field of Cloth of Gold | |
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| c. 1520 |
| | | Thomas Cromwell’s sister Katherine and her husband Morgan Williams move into the Mortlake house inherited from Morgan’s uncle John Williams | |
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| 1520 |
| | | Eighty distinguished Swedish citizens are executed together on the main square, in what becomes known as the Stockholm Bloodbath | |
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| c. 1520 |
| | | Mannerism develops in Italy in the work of the painters Pontormo and Rosso Fiorentino | |
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| 1521 |
| | | Pope Leo X excommunicates Martin Luther after he has refused to recant | |
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| 1521 |
| | | Portuguese explorer Ferdinand Magellan crosses the Pacific in ninety-nine days and reaches Guam | |
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