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| 1504 |
| | Babur captures Kabul, making it and eastern Afghanistan the first possession of the Mughal empire | |
| | Babur in a garden Fotofile CG
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| 1505 |
| | The Portuguese establish a presence in Sri Lanka, trading in the island's crop of cinammon | |
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| c. 1505 |
| | Leonardo captures the enigmatic smile of Lisa Gherardini, known now as the Mona Lisa | |
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| 1505 |
| | Pope Julius II summons Michelangelo to Rome to create the pope's own elaborately sculpted tomb | |
| | One of the 'slaves' for the tomb of Julius II Fotofile CG
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| 1505 |
| | St Peter’s is rebuilt, retaining some Norman work in the chancel from the original ‘chapelry’ | |
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| 1506 |
| | Julius II, together with the architect Bramante, lays the foundation stone for the new St Peter's | |
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| 1507 |
| | The editor of a pamphlet proposes that the recently found continent should be named America after the explorer Amerigo Vespucci | |
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| 1508 |
| | Michelangelo begins work in Rome on the ceiling of the Sistine chapel | |
| | Study for The Creation of Adam Michelangelo, c.1508 British Museum
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| 1508 |
| | Raphael is summoned to Rome by Julius II and is given a major commission for frescoes | |
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| 1509 |
| | Raphael begins work on the frescoes in the pope's apartment in the Vatican, known as the Stanze ('Rooms') | |
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