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| 1601 |
| | | Shakespeare's central character in Hamlet expresses both the ideals of the Renaissance and the disillusion of a less confident age | |
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| 1602 |
| | | The Dutch East India Company is founded, with a tax-free monopoly of the eastern trade for twenty-one years | |
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| 1603 March 23 |
| | | Queen Elizabeth I dies at the age of 69 in Richmond Palace | |
|  | The last known letter of Elizabeth I, 1603
National Archives, Kew
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| 1603 |
| | | Geneva wins independence from the duchy of Savoy, in the treaty of St Julien, after repelling a midnight assault on the city | |
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| 1603 |
| | | The warlord Tokugawa Ieyasu is awarded the title of shogun, beginning nearly three centuries of the Tokugawa shogunate | |
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| 1603 |
| | | James VI of Scotland inherits peacefully the crown of his English cousin Elizabeth, and becomes James I of England | |
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| 1603 |
| | | The accession of James I and VI to the throne of England brings the union of the crowns of England and Scotland | |
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| 1604 |
| | | The British king James I launches a blistering attack on the smoking of tobacco, which he considers a loathsome custom | |
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| 1604 |
| | | The first false Dmitry marches into Russia with a Polish army to claim the throne | |
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| 1604 |
| | | Annibale Carracci completes an influential ceiling fresco in the Farnese palace in Rome | |
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