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| 1543 |
| | | Humayun, driven west into Afghanistan by Sher Shah, loses his family's new inheritance in India | |
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| 1545 |
| | | Rich seams of silver are discovered at Potosi, in modern Bolivia | |
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| 1545 |
| | | 3000 Waldenses are massacred as heretics in the villages of Provence | |
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| 1545 |
| | | Ambroise Paré, the greatest surgeon of his day, publishes an account of how to treat gunshot wounds | |
|  | Artificial hand designed by Ambroise Paré
Wellcome Library, London
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| 1545 |
| | | The Italian players of the commedia dell'arte first feature in the records in this year | |
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| 1545 |
| | | A council of the Roman Catholic church is convened in Trent, to establish the tenets of the Counter-Reformation | |
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| 1546 |
| | | David Beaton, the archbishop of St Andrews, burns a leading Protestant, George Wishart, as a heretic and is murdered in retaliation | |
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| 1547 |
| | | Hungary is divided, by agreement between the Turkish sultan Suleiman I and the Habsburg ruler Ferdinand I | |
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| 1547 |
| | | On the death of Henry VIII his 10-year-old son becomes king of England as Edward VI | |
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| 1547 |
| | | Ivan IV is crowned tsar of Russia and becomes known as Ivan the Terrible | |
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