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| c. 1520 |
| | | Thomas Cromwell’s sister Katherine and her husband Morgan Williams move into the Mortlake house inherited from Morgan’s uncle John Williams | |
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| 1520 |
| | | Eighty distinguished Swedish citizens are executed together on the main square, in what becomes known as the Stockholm Bloodbath | |
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| c. 1520 |
| | | Mannerism develops in Italy in the work of the painters Pontormo and Rosso Fiorentino | |
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| 1521 |
| | | Pope Leo X excommunicates Martin Luther after he has refused to recant | |
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| 1521 |
| | | Portuguese explorer Ferdinand Magellan crosses the Pacific in ninety-nine days and reaches Guam | |
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| 1521 |
| | | Luther travels to the German city of Worms to present his case to an imperial diet | |
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| 1521 |
| | | Ferdinand Magellan is killed in the Philippines, in a skirmish with natives | |
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| 1521 |
| | | Luther bears witness to a Protestant conscience, stating at Worms: 'Here I stand, I can not do otherwise.' | |
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| 1521 |
| | | The Turkish sultan, Suleiman I, marches into the kingdom of Hungary and captures Belgrade | |
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| 1521 |
| | | After a little more than a year Cortes recaptures Tenochtitlan and finally establishes Spanish control over Mexico | |
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