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| 1493 |
| | | The Nuremberg Chronicle integrates text and pictures in an ambitious history of the world | |
|  | Nuremberg Chronicle
Fotofile CG
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| 1493 |
| | | John Williams, a brewer, acquires half an acre of land beside the Thames in Mortlake and builds on it a house subsequently known as Cromwell House | |
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| 1494 |
| | | In negotiations about the New World at Tordesillas, the king of Portugal insists on a new demarcation line which later brings him Brazil | |
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| 1494 |
| | | Charles VIII, king of France, marches through the Alps with an army of 30,000, to claim the throne of Naples | |
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| 1494 |
| | | Piero de' Medici and his brothers flee from Florence, after a mob ransacks the Medici palace | |
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| 1495 |
| | | Charles VIII captures Naples in February and is crowned there in May, but is forced back across the Alps before the end of the year | |
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| c. 1495 |
| | | Dürer, the first great artist to tackle the complexities of printing, becomes a master of woodcut and engraving | |
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| c. 1495 |
| | | The type faces known as roman and italic are created in Venice by the printers Nicolas Jenson and Aldus Manutius | |
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| 1496 |
| | | Diego Columbus, brother of the explorer, establishes the first secure Spanish colony at Santo Domingo | |
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| 1496 |
| | | Philip, heir to Austria, marries Joanna, a daughter of Ferdinand and Isabella of Spain, in the second of the great Habsburg marital alliances | |
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