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 Speaker (in houses of parliament)
 Speakers' Corner (London)
  - Donald Soper
 Spearman, Charles - and IQ tests
 Spear of the Nation - Umkhonto we Sizwe
 spears - in Stone Age
  - and throwing devices
 Special Branch (police) - formed in 1883
 species - and John Ray
 Species plantarum - by Linnaeus
 Specimens of Polyautography - 1803-7
 SPECT - and investigations of brain function
 spectacles - first use
 Spectator - Steele and Addison
  - brief account
 Spee, Graf von - German admiral
 speech - origins
 Speech from the Throne - in parliament
 Speed, John (cartographer)
 speed of light - calculated in 1676
 Speer, Albert - at the Nuremberg trials
 Speke, John Hanning - source of the Nile
  - on Tutsi and Hutu
  - brief biography
 Speke Hall, Liverpool
 Spence, Basil
  - and Coventry cathedral
 Spencer, Herbert - and evolution
 Spencer, Stanley
  - and Cookham
 Spender, Stephen
 Spenser, Edmund
  - brief biography
 Spenta Mainyu - in Zoroastrianism
 spermatozoa - observed by Leeuwenhoek
 Speyer - diets in 1526 and 1529
 Sphinx - at Giza
 sphygmomanometer - history
  - and the stethoscope
  - ambulatory monitors
 Spice Islands - or Moluccas
 spice trade - Portuguese
 spindle - origin
 spinning jenny - invented by Hargreaves
 Spirituals - among the Franciscans
 Spiritual Exercises - of Ignatius Loyola
 Spitalfields (London)
 Spitfire (aircraft)
  - in the Battle of Britain
 Spithead (off Portsmouth)
 Spitsbergen - sighted by Barents
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